I'm not sure I'm the best representation to speak for all of humanity about things that we're supposed to find weird, but if I had to guess, it's the vast endlessness and the incomprehensible scope of time? And the unknown. Humanity has a pretty good imagination. If you leave them a vacancy, they tend to fill it in with the worst, most horrifying possibilities they're capable of conceiving of.
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That explains a lot about the excellent story-telling, but persistent crippling anxiety.
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